Caryocar villosum attenuates inflammation by inhibiting CXCL1 activation and peripheral hyperalgesia through opioid pathway modulation

ABSTRACT The oil of Caryocar villosum is used in Amazonian folk medicine to treat pain and inflammatory conditions. So, we assessed the anti-inflammatory antinociceptive properties ethanolic extract obtained from fruit peels this species. acetic acid-induced writhing, carrageenan-induced mechanical hyperalgesia, formalin, paw edema peritonitis tests were on mice. C. significantly inhibited number abdominal writhes, hyperalgesia licking time second phase formalin test. At a dose 300 mg kg-1, also reduced volume formed late recruitment leukocytes neutrophils peritoneal cavity, as well CXCL1 chemokine levels. It suggested that attenuates leukocyte by inhibiting activation. peripheral activity occured through opioid pathway modulation because pretreatment with reversed naltrexone-induced antinociception.